Publications
2022
An action potential initiation mechanism in distal axons for the control of dopamine release
Changliang Liu#, Xintong Cai, Andreas Ritzau-Jost, Paul Kramer, Yulong Li, Zayd M Khaliq, Stefan Hallermann, and Pascal Kaeser#
Science, 375(6587):1378-1385. Mar 25, 2022. (PMID: 35324301)
# Corresponding Author
Highlighted in Nature Neuroscience and Nature Reviews Neuroscience
Media Coverage: Harvard News, ScienceDaily, Sciencenet(cn)
Molecular and functional architecture of striatal dopamine release sites
Aditi Banerjee, Cordelia Imig, Karthik Balakrishnan, Lauren Kershberg, Noa Lipstein, Riikka-Liisa Uronen, Jiexin Wang, Xintong Cai, Fritz Benseler,
Jeong Seop Rhee, Benjamin Cooper, Changliang Liu, Sonja Wojcik, Nils Brose, and Pascal Kaeser
Neuron, 110, 1-18, Jan 19, 2022 (PMID: 34767769)
2021
Spatial and temporal scales of dopamine transmission
Changliang Liu, Pragya Goel, and Pascal Kaeser
Nature Reviews Neuroscience, Apr 9, 2021. (PMID: 33837376)
2020
Synapse assembly in the absence of presynaptic Ca2+ channels and Ca2+ entry
Richard Held*, Changliang Liu*, Kunpeng Ma*, Austin Ramsey, Tyler Tarr, Giovanni De Nola, Shanshan Wang, Arn van den Maagdenberg, Toni
Schneider, JIanyuan Sun, Thomas Blanpied, and Pascal Kaeser.
Neuron, 107 1-17, Aug19, 2020. (PMID: 32616470)
* Equal Contribution
Recommended by F1000
Media Coverage: Previewed in Neuron
Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
Aditi Banerjee, Jinoh Lee, Paulina Nemcova, Changliang Liu, and Pascal Kaeser
eLife, 3;9:e58359. doi: 10.7554/eLife.58359, Jun 3, 2020. (PMID: 32490813)
Targeting the cholinergic system in Parkinson’s disease
Changliang Liu
Acta Pharmacologica Sinica, 41 453-463. Mar 4, 2020. (PMID: 32132659)
2019
Nanoscale location matters: emerging principles of Ca2+ channel organization at the presynaptic active zone
Changliang Liu and Pascal Kaeser
Neuron, 104(04):627-629. Nov20,2019. (PMID:31751541)
Mechanisms and regulation of dopamine release
Changliang Liu and Pascal Kaeser
Current Opinion in Neurobiology, 57:46-53, 2019. (PMID: 30769276)
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
Jiali Song, Chengzhi Qiang, Kongkai Zhu, Luis Alexandre Muehlmann, Chengshi Jiang#, Changliang Liu#, and Hua Zhang#
Bioorganic Chemistry, 83:277-288, Oct 29, 2019. (PMID: 30391700)
# Corresponding Author
2018
Dopamine secretion is mediated by sparse active zone-like release sites
Changliang Liu, Lauren Kershberg, Jiexin Wang, Shirin Schneeberger, Pascal S. Kaeser
Cell, 172, 706-718, Feb 8, 2018. (PMID: 29398114)
Highlighted in Nature Reviews Neuroscience
Media Coverage: ScienceDaily, Nature Reviews Neuroscience
Liprin-α3 controls active zone composition, synaptic vesicle docking and exocytosis in hippocampal nerve terminals
Manyan Wong, Changliang Liu, Aram C.f. Roquas, Stephen Fowler, Pascal S, Kaeser
PNAS, 115(9)2234-2239, Feb 27 2018. (PMID: 29439199)
Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral Tegmental Area
Changliang Liu, Yakun Wang, Guozhang Jin, Weixing Shi, Ming Gao
Sci Rep., 8:3274, Feb 19, 2018. (PMID: 29459754)
Before 2018
ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains
Richard Held, Changliang Liu, and Pascal Kaeser
eLife, 5:e14862. Jun 2, 2016. (PMID: 27253063)
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking
Shanshan Wang, Richard Held, Manyan Wong, Changliang Liu, Aziz Karakhanyan, and Pascal Kaeser
Neuron, 91, 777–791, Aug 17, 2016. (PMID: 27537483)
Media Coverage: The Scientist
The Active Zone Protein Family ELKS Supports Ca2+ Influx at Nerve Terminals of Inhibitory Hippocampal Neurons
Changliang Liu, Lydia Bickford, Richard Held, Hajnalka Nyitrai, Thomas Südhof, and Pascal Kaeser
The Journal of Neuroscience, 34(37):12289 –12303, Sep 10, 2014. (PMID: 25209271)
Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area
Changliang Liu, Xing Fang, Qianqian Wu, Guozhang Jin, and Xuechu Zhen
Neuropharmacology, 95:299-308, Apr 14, 2015. (PMID: 25882828)
GABA neurons in the ventral tegmental area responding to peripheral sensory input
Changliang Liu, Ming Gao, Guozhang Jin, and Xuechu Zhen
PloS ONE., 7:12:e51507 Dec 10, 2012. (PMID: 23251560)
Functional Coupling Between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area
Ming Gao, Changliang Liu, Shen Yang, Guozhang Jin, Bunney BS, and Weixing Shi
The Journal of Neuroscience, 27(20):5414–5421, May 16, 2007. (PMID: 17507563)
l-Stepholidine increases the frequency of sEPSC via activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons
Ming Gao, Changliang Liu, Shen Yang, Xuechu Zhen, and Guozhang Jin
Acta Pharmacologica Sinica, 28 (5): 627–633, May 2007. (PMID: 17439718)